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The OptiSafe Ocular Irritation Test (OECD 496)
The OptiSafe (OS) Eye Irritation Test™ (EIT) method consists of a macromolecular test matrix composed of plant-derived proteins, lipids, and nucleotides that does not include any animal ingredient or component. The method measures the extent of damage of the macromolecular matrix upon exposure to a test chemical, and the measured extent of macromolecular damage is used to predict the toxicity of the tested chemical to the eye.
The OS assay is an independently validated macromolecular test method to identify chemicals that do not require classification for eye irritation or serious eye damage as defined by the Organization for Economic Cooperation and Development (OECD) Test Guideline 496.
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The In Vitro Depth of Injury (IVD) Eye Irritation Test (IVD EIT)
The IVD EIT uses otherwise discarded food-source animal eyes. The method applies materials to be tested to the ocular surface, rinses with a tear solution and measures direct and metabolic related depth-dependent viability loss. The IVD EIT accuracy for each GHS eye toxicity regulatory classification (NC, 2B, 2A and 1) is close to or greater than 90%. The multiple category applicability is unique and addresses the unmet need for an in vitro eye irritation test to correctly label GHS Category 2A materials to ensure that users are properly warned when to wear eye protection to avoid eye injury.
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The DermaSafe Skin Corrosion Test (DermaSafe SCT™)
The in chemico DermaSafe SCT measures the dermal corrosivity of a test material. The extent of dermal corrosion is classified based on the ability of a chemical to corrode a skin biomarker. The simple and rapid procedure involves adding the material to be tested to a tube filled with a marker for skin corrosion, incubating the material at room temperature, and then adding a colorimetric reagent to measure the marker using either a laboratory plate reader (high-throughput method) or visually (field method).
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